Endocrine Abstracts

Background: Perfluoroalkyl substances (PFAS) are endocrine disrupting chemicals, with elimination half-lives ranging from four to eight years. Experimental studies indicate that PFAS may disrupt androgenic and estrogenic pathways, potentially affecting fetal development. During 1st trimester, concentrations of sex hormone-binding globulin (SHBG) increase due to higher estrogen levels from the placenta. The increment of SHBG concentration results in a compensatory increase in t...

Background: Perfluoroalkyl substances (PFAS) are endocrine disrupting chemicals, with elimination half-lives ranging from four to eight years. Experimental studies found PFAS able to interfere with thyroid hormone-binding proteins. During the first 20 weeks of gestation (GW), the fetus is reliant on placental transfer of maternal thyroid hormones, mainly free thyroxine (FT4). However, previous studies investigating associations between exposure to PFAS and thyroid hormone stat...